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DGL LIcorice Root

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Background

Licorice has been used in ancient Greece, China, and Egypt, primarily for gastritis (inflammation of the stomach) and ailments of the upper respiratory tract. Ancient Egyptians prepared a licorice drink for ritual use to honor spirits of the pharaohs. Its use became widespread in Europe and Asia for numerous indications.

Licorice has a long history of medicinal use in Europe and Asia. At high doses, there are potentially severe side effects, including hypertension (high blood pressure), hypokalemia (low blood potassium levels), and fluid retention. Most adverse effects have been attributed to the chemical component glycyrrhiza (or glycyrrhizic acid). Licorice can be processed to remove the glycyrrhiza, resulting in DGL (deglycyrrhizinated licorice), which does not appear to share the metabolic disadvantages of licorice.

Health Benefits

Adrenal insufficiency (Addison's disease)
Historically patients took common salt and plant-based preparations, including licorice.

Atopic dermatitis
Topical licorice extract gel has been shown to be effective in the treatment of atopic dermatitis.

Functional dyspepsia
Early studies indicate that licorice may help improve symptoms in patients with functional dyspepsia.

Herpes simplex virus
Laboratory studies have found that DGL may hinder the spread and infection of herpes simplex virus. Studies in humans suggest that topical application may improve healing and prevent recurrence.

HIV
Early studies suggest that glycyrrhizin may inhibit HIV replication in patients with AIDS.

Inflammation
Because licorice can affect the metabolism of steroids, licorice is sometimes used to help decrease inflammation.

Polycystic ovarian syndrome
Licorice has been used in combination with spironolactone to reduce side effects related to the diuretic activity of spironolactone.

Reducing body fat mass
Preliminary data shows that licorice may reduce body fat mass.

Upper respiratory tract infections
Historically, licorice has been used for its expectorant and anti-tussive effects.

Viral hepatitis
The licorice extracts DGL and carbenoxolone have been proposed as possible therapies for viral hepatitis.

Dosage

Adults (18 years and older) Licorice powdered root (4 percent to 9 percent glycyrrhizin): Doses of 1-4 grams taken by mouth daily, divided into three or four doses, have been used.

Children (younger than 18 years) There is not enough scientific evidence to recommend licorice for use in children, and licorice is not recommended due to potential side effects. .

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